To test this hypothesis, we conducted an ancillary study within the Personalized Prevention of Colorectal Cancer Trial (PPCCT), which is a double-blind, placebo-controlled, randomized controlled trial (This is a US National Cancer Institute (NCI)–funded ancillary study (registered at Flow diagram of trial recruitment and retention.
Note publique d'information : Percussionniste. In all cases the Ref.
The interaction between treatment and baseline 25(OH)D was also included in the models.
None of the authors had a conflict of interest.This study was supported by R01 CA149633, R03 CA189455, and R01 CA202936 from the National Cancer Institute, Department of Health and Human Services as well as the Ingram Cancer Center Endowment Fund.
| YU CHANG 2020 Topps Finest Flashbacks Ref Refractor /50 INDIANS RC2020 Topps Finest Flashbacks Refractor #188 Austin Meadows Tampa Bay Rays2020 Topps Finest Flashbacks Gold Refractor #192 JD Davis 40/50 New York Mets2020 Topps Finest Flashbacks Gold Refractor #169 Mike Yastrzemski 37/50 Giants2020 Topps Finest Flashbacks Refractor #44 Tim Anderson Chicago White Sox2020 Topps Finest Flashbacks Gold Refractor #154 Nick Solak RC Rangers 47/502020 Topps Finest Flashbacks Gold Refractor #180 Brendan McKay RC 18/502020 Topps Baseball's Finest Flashbacks Refractor #57 Dylan Cease RC White Sox2020 Topps Baseball's Finest Flashbacks #5 Yu Chang RC Rookie Cleveland Indians2020 Topps Chrome Base Negative Refractor #173 Yu Chang RC - Cleveland Indians2020 Topps Finest Flashbacks Black Refractor #46 Adam Civale 01/25 IndiansDR. (A) Adjusted to 25(OH)DRelation between magnesium treatment and vitamin D metabolism, by baseline 25(OH)D concentrationsRelation between magnesium treatment and vitamin D metabolism, by baseline 25(OH)D concentrationsIn the parent study (PPCCT), 250 participants were allocated to either the magnesium treatment or placebo arm and began the treatment. Item Information. According to NHANES, 79% of US adults do not meet their Recommended Dietary Allowance of magnesium.The aim of this study was to test the hypothesis that magnesium supplementation differentially affects vitamin D metabolism dependent on baseline 25-hydroxyvitamin D [25(OH)D] concentration.The study included 180 participants aged 40–85 y and is a National Cancer Institute independently funded ancillary study, nested within the Personalized Prevention of Colorectal Cancer Trial (PPCCT), which enrolled 250 participants. To note, the other 5 withdrew due to lack of time or interest.The participants in the magnesium treatment arm did not significantly differ from those in the placebo arm with regard to averages or distributions for age, sex, BMI, eGFR, Descriptive characteristics of 180 participants at baselineDescriptive characteristics of 180 participants at baselineThe relations of magnesium treatment with the plasma concentrations of 25(OH)DWhen the baseline 25(OH)D was higher, at ∼30–50 ng/mL, magnesium treatment reduced 25(OH)DWe found that magnesium supplementation interacted with baseline plasma concentrations of 25(OH)D in affecting the concentrations of 25(OH)DBoth in vitro and in vivo studies have indicated that magnesium deficiency affects 1α-hydroxylase (i.e., CYP27B1) and 24-hydroxylase (i.e., CYP24A1), which synthesize and metabolize 25(OH)D and 1,25(OH)Thus, the findings from the current study provide the first evidence in humans that magnesium supplementation reduces 25(OH)DIn this study, we found that magnesium supplementation increased plasma concentrations of 25(OH)DThe current study has several strengths, including the randomized, placebo-controlled design. The parent PPCCT was still blinded for primary outcomes; thus, an unblinded independent statistician outside of the study team conducted all the statistical analyses for the current report.Two 24-h dietary recalls were performed for all participants at the baseline of the PPCCT. For additional information, see the Global Shipping Program This amount includes applicable customs duties, taxes, brokerage and other fees. Changes in plasma 25-hydroxyvitamin DThe relations between magnesium treatment and plasma concentrations of 25(OH)DOur findings suggest that optimal magnesium status may be important for optimizing 25(OH)D status. This assay of vitamin D metabolites is validated by participation in quality-assurance programs organized by DEQAS (the Vitamin D External Quality Assessment Scheme) and the National Institute of Standards and Technology (NIST). Chang, Ying-Yu.
Postnatal adaptations of phosphatidylcholine metabolism in extremely preterm infants: implications for choline and PUFA metabolism
Anthropometric measurements (weight, height, and waist and hip circumferences) were measured at least twice at each clinic visit.Blood was collected from a forearm vein at each clinic visit after participants had fasted for ≥8 h. Both serum and plasma were rapidly cooled and frozen at −80°C before biochemistry analysis. We did find that 3 of the interactions were statistically significant and remained significant after Bonferroni corrections; however, we cannot eliminate the possibility that we did not have sufficient statistical power to detect the interaction between magnesium supplementation and baseline 25(OH)D on 1,25(OH)In summary, among individuals with calcium-to-magnesium intake ratios ≥2.6, who account for >76% of the US general adult population, magnesium supplementation increases 25(OH)DThe authors’ responsibilities were as follows—QD and MJS: contributed to the hypothesis development and to the manuscript preparation; QD, MJS, CY, and DLS: contributed to the study design; HN and XZ: were responsible for the data analysis; QD, XL, and AAF: contributed to the assay of the vitamin D metabolites; XZ, JEM, YS, XL, AAF, RBC, AR, HN, LF, HM, RMN, DLS, CY, and MJS: contributed to the data interpretation and manuscript revision; and all authors: read and approved the final manuscript. Search for other works by this author on:
Center for Magnesium Education and Research, Pahoa, HI
Dark gray indicates deactivating enzymes, and light gray indicates activating enzymes. We found that the calcium-to-magnesium ratios remained stable.
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